Keywords
transmission
resistance
re-emergence
Glycyrrhiza
How to Cite
Abstract
Swine flu (A H1N1), a quadruple reassortant virus, causes respiratory illness in people. It is a new influenza virus, first detected in people in the United States in April 2009. It is a global threat, affecting more than 70 countries. The case fatality rate (CFR) of the pandemic strain has been estimated at 0.4%. In India, 1927 laboratory confirmed cases of novel influenza A H1N1 have been reported with 25 deaths. The novel H1N1 virus spreads from human to human, in similar way that of regular seasonal influenza viruses, and their clinical presentation imitate seasonal flu; sometimes diarrhea, vomiting, severe illnesses and death have also been reported. The virus is resistant to amantadine and rimantadine and sensitive to oseltamivir and zanamivir. However, oseltamivir resistant strains have also emerged. Use of approved N95 filtering face piece respirators, powered air purifying respirators during flu patient care and medical procedures have been recommended. ASO3 adjuvant pandemic (H1N1) 2009 vaccine have been found effective in preventing pandemic (H1N1) 2009 disease. Different technologies such as intranasal administered SAP, multimeric forms of the 2009 A(H1N1) HA (sHA) and NA (sNA) surface glycoproteins, ty/04 att-based vaccines, licochalcone G and chalcones from the acetone extract of Glycyrrhiza inflata are being thought of and explored to control and treat influenza. Generalized lymphopenia, preferential loss of Th17 population and T cell activation and radiological imaging have been indicated for earlier diagnosis. The phylogenetic studies indicate 2009 novel H1N1 origin from that of the 1918 pandemic strain. Undoubtedly we are heading towards unraveling the mysteries of the influenza virus, but it seems to be far more tactical to prevail, emerge or re- emerge. Thus, potentially threatening challenge still surrounds us.
References
Andrews N, Waight P, Yung CF, Miller E. 2011. Age-Specific Effectiveness of an Oil-in-Water Adjuvanted Pandemic (H1N1) 2009 Vaccine Against Confirmed Infection in High Risk Groups in England. J Infect Dis.; 203(1):32-39.
Anhlan D, Grundmann N, Makalowski W, Ludwig S, Scholtissek C. 2010. Origin of the 1918 pandemic H1N1 influenza A virus as studied by codon usage patterns and phylogenetic analysis. RNA. Nov 10. [Epub ahead of print].
Bell EA. June 2009. Pharmacotherapy of novel influenza A (H1N1). Infect Dis Children.
Bosch BJ, Bodewes R, de Vries RP, Kreijtz JH, Bartelink W, van Amerongen G, Rimmelzwaan GF, de Haan CA, Osterhaus AD, Rottier PJ. 2010. Recombinant soluble, multimeric HA and NA exhibit distinctive types of protection against pandemic swine-origin 2009 A(H1N1) influenza virus infection in ferrets. J Virol., 84(19):10366-74.
Cal/OSHA. 2009. Guidance for Employers and Employees Regarding Recent H1N1 (Swine Flu) Cases UPDATED July 15.
Centers for Disease Control and Prevention (CDC) 2009. Update: swine influenza A (H1N1) infections-California and Texas, April 2009, MMWR Morb. Mortal Wkly. Rep., 58 (2009) 1-3.
Centers for Disease Control and Prevention (CDC) article Intrim Guidance for H1N1 Flu (Swine Flu): Taking Care of a Sick person in your home updated regularly. Available from: http://www.cdc.gov/h1n1flu/guidance_homecare.htm.
Centers for Disease Control and Prevention (CDC). 2009. Swine influenza A (H1N1) infection in two children-southern California, March-April 2009, MMWR Morb. Mortal Wkly. Rep., 58:400-402.
Centers for Disease Control and Prevention. 2010. Interim guidance for infection control for care of patients with confi rmed or suspected novel infl uenza A (H1N1) virus infection in a healthcare setting. http://www.cdc.gov/h1n1flu/guidelines_infection_control.htm
Dao TT, Nguyen PH, Lee HS, Kim E, Park J, Lim SI, Oh WK. 2010. Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata. Bioorg Med Chem Lett. Nov 5. [Epub ahead of print].
Deadly new flu virus in US and Mexico may go pandemic. New Scientist. April 28, 2009. Available from: http://www.webcitation.org/5gNd9HTT9.
Fraser, Christophe, Christl Donnelly A, Simon Cauchemez, William P. Hanage,Maria D. Van Kerkhove, T. Déirdre Hollingsworth, Jamie Griffin1, Rebecca F. Baggaley, Helen E. Jenkins, Emily J. Lyons, 2009. Pandemic potential of a strain of influenza A(H1N1) : early findings (PDF). Science 324(5934): 1557-1561. Available from: http://www.sciencemag.org/cgi/reprint/324/5934/1557.pdf
Graitcer SB, Gubareva L, Kamimoto L, Doshi S, vandermeer M, Louie J. 2009. Characteristics of patients with oseltamivir-resistant pandemic (H1N1) United St. Emerg Infect Dis. 2011 Feb; [Epub ahead of print].
Horváth A, Andersen I, Junker K, Lyck Fogh-Schultz B, Holm Nielsen E, Gizurarson S, Andersen O, Kármán J, Rajnavölgyi E, Erdei A, Svehag SE. 2001. Serum amyloid P component inhibits influenza A virus infections: in vitro and in vivo studies. Antiviral Res., 52(1):43-53.
Jiang TJ, Zhang JY, Li WG, Xie YX, Zhang XW, Wang Y, Jin L, Wang FS, Zhao M. 2010. Preferential loss of Th17 cells is associated with CD4 T cell activation in patients with 2009 pandemic H1N1 swine-origin influenza A infection.Clin Immunol. 137(3):303-10.
Mai BK, Viet MH, Li MS. 2010. Top Leads for Swine Influenza A/H1N1 Virus Revealed by Steered Molecular Dynamics Approach. J Chem Inf Model. Nov 23. [Epub ahead of print].
Mayo Clinic Staff. “Influenza (flu) treatments and drugs.” Diseases and conditions. Mayo Clinic. 2009. Available from: http://www.mayoclinic.com/health/influenza/DS00081/DSECTION=treatment-and drugs.
Mollura DJ, Morens DM, Taubenberger JK, Bray M. 2010. The role of radiology in influenza: novel H1N1 and lessons learned from the 1918 pandemic. J Am Coll Radiol., 7(9):690-97.
Novel H1N1 Novel Influenza (Swine flu). 2009. Available from: http://www.cidrap.umn.edu/cidrap/content/influenza/swineflu/biofacts/swinefluoverview.htm.
Pandemic (H1N1) 2009- update 58 (6 july 2009 09:00 GMT). Laboratory confirmed cases of pandemic (H1N1) 2009 as officially reported to WHO by States Parties to the International Health Regulations (2005). Available from: http://www.who.int/csr/don/2009 07 06/en/index.html.
Pandemic H1N1 flu. Available from: http://www.oregon.gov.
Pena L, Vincent AL, Ye J, Ciacci-Zanella JR, Angel M, Lorusso A, Gauger PC, Janke BH, Loving CL, Perez DR. 2010. Modifications in the polymerase genes of a swine-like triple reassortant influenza virus to generate live attenuated vaccines against 2009 pandemic H1N1 viruses. J Virol. Oct 20. [Epub ahead of print].
Safronetz D, Rockx B, Feldmann F, Belisle SE, Palermo RE, Brining D, Gardner D, Proll SC, Marzi A, Tsuda Y, Lacasse RA, Kercher L, York A, Korth MJ, Long D, Rosenke R,Shupert WL, Alpuche Aranda C, Mattoon JS, Kobasa D, Kobinger G, Li Y, Taubenberger JK, Richt JA, Parnell M, Ebihara H, Kawaoka Y, Katze MG, Feldmann H. 2010. Pandemic Swine-Origin H1N1 Influenza A Isolates Show Heterogeneous Virulence in Macaques. J Virol. Nov 17. [Epub ahead of print].
Sinha NK, Roy A, Das B, Das S, Basak S. 2009. Swine flu complexities of swine flu H1N1 gene sequences of 2009. Biochem. Biophys. Res. Commun. 2009, doi: 10.1016/j.bbrc. 09.060.
Smith GJ, Vijaykrishna D, Bahl J, Lycett SJ, Worobey M, Pybus OG, Ma SK, Cheung CL, Raghwani J, Bhatt S, Peiris JS, Guan Y, Rambaut A. 2009. Origins and evolutionary genomics of 2009 swine origin H1N1 influenza A epidemic, Nature 459:1122-25.
Swine Flu India: latest updates, alerts, precautions, prevention. Available from: http://www.swineflu-india.org/
Tang JW, Shetty N, Lam TT. 2010. Features of the new pandemic influenza A/H1N1/2009 virus: virology, epidemiology, clinical and public health aspects. Curr Opin Pulm Med., 16(3):235-41.
US Centers for Disease Control. 2008. “Infection Control Guidance for the prevention and control of Influenza in Acute care facilities.” Available from: http://www.cdc.gov/flu/professionals/infectioncontrol/healthcarefacilities.htm.
“What to do if you get flu like symptoms” Centers for Disease Control and Prevention. 7 May 2009. Available from: http://www.cdc.gov/h1n1flu/sick.htm.
“WHO: swine flu pandemic has began, 1st in 41 years” 2009. The associated press. June 11, Available from: http://www.google.com/hostednews/ap/article/ALeqM5jTkkEKE5LtPih_5Jcc3MpD0gOYQD98O H0U00
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