Journal of Research in Biology Biology Journal Journal of Biology Biology research journal biomedical journal
Phytochemical and pharmacological properties of certain medicinally important species of Cucurbitaceae family – a review
PDF
HTML

Keywords

Cucurbitaceae
traditional uses
phytochemicals
pharmacological activities

How to Cite

S, J., K, K., & S, P. (2015). Phytochemical and pharmacological properties of certain medicinally important species of Cucurbitaceae family – a review. Journal of Research in Biology, 5(6), 1835-1849. Retrieved from https://ojs.jresearchbiology.com/index.php/jrb/article/view/398

Abstract

Cucurbits are edible crops, belonging to the family Cucurbitaceae. They are climbers with reserves in roots and are distributed mainly in tropical zones. They are mostly moist vines and are distributed in both the eastern and western hemispheres. The member of this family are excellent fruit crops having most of the essential nutrients, vitamins and minerals required for the good health of humans. All parts of the Cucurbitaceae plants (leaf, stem, root or tuber, fruit and seeds) are used in the traditional system of medicine. Wide research is going on to search a new active compound and to analyze their medicinal properties. The present review of Cucurbitaceae family deals with the very large amount of updated information of scientific research and report in the field of phytochemistry and pharmacology. In this study, we have documented some of the important plants viz., Mukia maderaspatana, Solena amplexicaulis, Citrullus colocynthis, Citrullus lanatus, Coccinia indica, Cucumis sativus, Cucurbita pepo, Lagenaria siceraria, Luffa acutangula, Trichosanthes cucumerina, Corallocarpus epigaeus, Luffa cylindrica, Momordica charantia, Trichosanthes dioica and Kedrostis foetidissima.

PDF
HTML

References

Abbas D, Simon G, Ali Reza K, Hossein M, Masoud M, Lutfun N and Satyajit DS. (2006). Flavone C-glycosides and cucurbitacin glycosides from Citrullus colocynthis. DARU, 14(3):109-114.

Abubakar NS, Florence IO and Iyanu OO. (2014). Phytochemcial screening and hypoglycemic effect of methanolic fruit pulp extract of Cucumis sativus in alloxan induced diabetic rats. Journal of Medicinal Plant Research, 8(39):1173-1178.

Ahmed SKM and Manoj J. (2012). Antiobesity activity of Coccinia indica in female rats fed with cafeteria and antherogenic diets. Der Pharmacia Lettre, 4(5):1480-1485.

Alam MB, Hossain MS, Chowdhury NS, Asadujjaman M, Zahan R, Islam MM, Mazumder MEH, Haque ME and Islam A. (2011). Antioxidant, antiinflammatory and antipyretic activities of Trichosanthes dioica Roxb. fruits. Journal of Pharmacology and Toxicology, 6(5):440-453.

Amutha M and Lalitha P. (2013). Evaluation of wound healing activity of leaf and stem extract of Kedrostis foetidissima (Jacq.) Cogn. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 4(2):445-451.

Arun C, Satheesh Kumar R, Srinu S, Lal Babu G, Raghavendra Kumar G and Amos Babu J. (2011). Anti-inflammatory activity of aqueous extract of leaves of Solena amplexicaulis. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(4):1617-1619.

Arun Kumar S and Kumar EK. (2013). Hepatoprotective activity of aqueous fruit extract of Coccinia indica against paracetamol induced hepatotoxicity in rats. International Journal of Research in Pharmaceutical and Biomedical Sciences, 4(1):179-182.

Asgary S, Moshtaghian SJ, Setorki M, Kazemi S, Rafieian-Kopaei M, Adelnia A and Shamsi F. (2011). Hypoglycaemic and hypolipidemic effects of pumpkin (Cucurbita pepo L.) on alloxan-induced diabetic rats. African Journal of Pharmacy and Pharmacology, 5(23):2620-2626.

Ashok Kumar B, Jagadish S, Sasmita D and Tapan Kumar M. (2010). Antihyperglycemic and hypolipidemic effects of Melothria maderaspatana and Coccinia indica in streptozotocin induced diabetes in rats. Saudi Pharmaceutical Journal, 18(3):173-178.

Bagchi Indrani. (2005). Food for thought: Green ‘Karela’ for Red China. The Times of India.

Balakrishnan and Alka Sharma. (2013). Preliminary phytochemical and pharmacological activities of Luffa cylindrica L. fruit. Asian Journal of Pharmaceutical and Clinical Research, 6(2):113-116.

Bambal VC, Wyawahare NS, Turaskar AO and Deshmukh TA. (2011). Evaluation of wound healing activity of herbal gel containing the fruit extract of Coccinia indica Wight and Arn. (Cucurbitaceae). International Journal of Pharmacy and Pharmaceutical Sciences, 3(suppl 4):319-322.

Bavaji Naidu B, Palaksha MN, Ravishankar K, Naveen M and Basha N. (2014). Evaluation of antidiarrhoel and antiulcer activities of hydroalcoholic extract of Luffa aegyptiaca fruits. Research Journal of Pharmacology and Pharmacodynamics, 6(4):173-176.

Belsem M, Zohra M, Ehsen H, Manel T, Abderrrahman B, Mahjoub A and Nadia F. (2011). Anti-inflammatory evaluation of immature fruit and seed aqueous extracts from several populations of Tunisian Citrullus colocynthis Schrad. African Journal of Biotechnology, 10(20):4217-4225.

Caili F, Huan S and Quanhong L. (2006). A review on pharmacological activities and utilization technologies of pumpkin. Plant Foods for Human Nutrtion, 61(2):73-80.

Chandra SJ, Lakshmidevi N, Mruthunjaya K and Huded S. (2014). Medicinal plants used in tribal and folklore medicine in rural areas of Mysore district. International Journal of Biology, Pharmacy and Allied Sciences, 3(5):797-836.

Chandra SKB, Devanna N, Venkata Naga A, Sandhya RN, Sreenivasa KO, Jagadeeswara RK, Sreevani S and Sreekanth A. (2015). Evaluation of in vitro anticancer activity of ethanolic extract of Corallocarpus epigaeus on chronic myeloid leukaemia K562 cell lines. Journal of Comprehensive Pharmacy, 2(1):8-13.

Chandrakala AN, Harinatha reddy A, Nageswari G, Vani Sri DS, Shabana Begum S and Venkata B. (2013). Antivenom and immunomodulatory functions of Corallocarpus epigaeus L. International Journal of Pharma and BioSciences, 4(1):654-660.

Choene M and Motadi LR. (2012). Anti-proliferative effects of the methanolic extract of Kedrostis foetidissima in breast cancer cell lines. Molecular Biology, 1(2):107. Doi. 10. 4172/2168-9547. 1000107.

Daisy P, Jasmine R, Ignacimuthu S and Murugan E. (2009). A novel steroid from Elephantopus scaber L. an ethnomedicinal plant with antidiabetic activity. Phytomedicine, 16(2-3):252-257.

Deshmukh CD, Jain A and Tambe MS. (2015). Phytochemical and pharmacological profile of Citrullus lanatus (Thunb). Biolife, 3(2):483-488.

Deshpande JR, Choudhari AA, Mishra MR, Meghre VS, Wadodkar and Dorle AK. (2008). Benefial effects of Lagenaria siceraria (Mol.) Standley fruit epicarp in animal models. Indian Journal of Experimental Biology, 46(4):234-242.

Dhanaraj TS and Jegadeesan M. (2013). Antiulcer activity of ethanolic extract of root of Mukia maderaspatana (L.)Roemer. International Journal of Pharma and BioSciences, 4(1):395-400.

Dhanaraj TS, Murugaiah K and Sarmila. (2012). Antiulcer activity of Mukia maderaspatana on stress induced in rats. Asian Journal of Research in Pharmaceutical Sciences, 2(2):52-54.

Fahri Y, Salman E, Ozkan O, Zeybek D, Mustafa A, Ahmet D, Halit Y, F Kaymaz, Sunver, Mehmet K and Suheyla. (2013). The effect of Lagenaria siceraria (Molina) on acute lung injury induced by oleic acid in rats. World Journal of Surgical Research, 2(4):39-49.

Fathima M, Nair A and Tilton F. (2013).Anti-cancer potentials of Mukia maderasapatana (Linn.) M. Roem. Leaf against colo320 cells extracts. International Journal of Current Research, 5(2):409-412.

Giday M. (2001). An ethnobotanical study of medicinal plants used by the Zay people in Ethiopia. Skriftserie, 3:81-99.

Gill NS, Arora R and Ranjan Kumar S. (2011a). Evaluation of antioxidant, anti-inflammatory and analgesic potential of the Luffa acutangula Roxb. Var. amara. Research Journal of Phytochemistry, 5(4):201-208.

Gill NS and Bali M. (2011). Isolation of antiulcer cucurbitane type triterpenoid from the seeds of Cucurbita pepo. Research Journal of Phytochemistry, 5(2):70-79.

Gill NS, Kaur S, Arora R and Bali M. (2011b). Screening of antioxidant and antiulcer potential of Citrullus colocynthis methanolic seed extract. Research Journal of Phytochemistry, 5(2):98-106.

Gnananath K, Ramakanth Reddy K, Pavan Kumar G, Krishna B, Srinivas Reddy K and Sanjeeva Kumar A. (2013). Evaluation of antidiabetic activity in Corallocarpus epigaeus rhizomes. International Current Pharmaceutical Journal, 2(3):53-56.

Hayashida N, Chihara S, Tayama E, Takaseya T, Enomoto N, Kawara T and Aoyagi S. (2001). Anti-inflammatory effects of colforsin daropate hydrochloride, a novel water-soluble forskolin derivative. The Annals of Thoracic Surgery, 71(6):1931-8.

Hemalatha S, Shri Vijaya Kiruba T, Nagavalli D, Nisha Shri C, Balaji J, Venkataramanan S, Madumathi KL and Rajagopal RG. (2014). Antisnake venom activity of root and rhizome of Corallocarpus epigaeus. International Journal of Experimental Pharmacology, 4(3):145-147.

Hemalatha S, Wahi AK, Singh PN and Chansouria JPN. (2010). Evaluation of anti-hyperglycemic and free radical scavenging activity of Melothria maderaspatana Linn. in strptozotocin-induced diabetic rats. African Journal of Pharmacy and Pharmacology, 4(11):817-822.

Houcine B, Rachid A, Rabah D, Farid L, Nabila B and Boufeldja T. (2011). Effect of saponosides crude extract isolated from Citrullus colocynthis (L.) seeds on blood glucose level in normal and streptozotocin induced diabetic rats. Journal of Medicinal Plants Research, 5(31):6864-6868.

Howida Sayed AS. (2014). Ameliorative effect of pumpkin oil (Cucurbito pepo L.) against alcohol-induced hepatotoxicity and oxidative stress in albino rats. Beni-Suef Univerisity. Journal of Basic and Applied Sciences, 3(3):178-185.

Ismail M, Hussain MM, Dastagir MG, Billah M and Quader A. (2010). Phytochemical and antimicrobial investigation of Luffa cylindrical. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 9(4):327-332.

Jayaseelan M, Arumugam T and Thangaraj N. (2014). Evaluation of antioxidant and antiinflammatory activities of Corallocarpus epigaeus (Hook. F.) rhizomes. International Journal of Pharmaceutical and Biomedicial Research, 5(1):18-24.

Jutamas S, Sumonthip K, Nuttawan Y, Tanawan K and Weena J. (2015). Antibacterial and antiproliferative activities of plumericin, an iridoid isolated from Momordica charantia vine. Evidence-Based Complementary and Alternative Medicine. Article ID 823178, 10 pages.

Kabir MG, Rahman MM, Ahmed NU, Fakruddin M, Islam S and Mazumdar RM. (2014). Antioxidant, antimicrobial toxicity and analgesic properties of ethanol extract of Solena amplexicaulis root. Biological Research, 47(1):36.

Kanwal W, Waseemuddin Syed A, Salman A and Muhammad HM. (2013). Anti-emetic and anti-inflammatory activity of fruit peel of Luffa cylindrica (L.) Roem. Asian Journal of Natural and Applied Science, 2(2):75-80.

Karthika K. (2014). Current availability status, phytochemistry, therapectic properties and in vitro regeneration of the traditional medicinal climber, solena amplexicalulis (Lam.) Gandhi. (Cucurbitaceae). Thesis submitted to Bharathiar University, Coimbatore, Tamil Nadu, India.

Kharbanda C, Alam MS, Hamid H, Javed K, Bano S, Ali Y, Nazreen S and Haider S. (2015). Ameliorative effects of Trichosanthes dioica extract in suppressing inflammatory mediators and attenuating oxidative stress. Planta Medicine, 81(5):348-356.

Khare CP. (2007). Encyclopedia of Indian medicinal plants. Springer science, Business Media.p. 458.

Kirana H and Srinivasan BP. (2008). Trichosanthes cucumerina Linn. Improves glucose tolerance and tissue glycogen in non insulin dependent diabetes mellitus induced rats. Indian Journal of Pharmacology, 40(3):103-106.

Kirtikar KR. and Basu BD. (1996). Indian Medicinal Plants. In: (ed. 2) Allahabad (India): Lalit Mohan Basu 1664.

Kirtikar KR. and Basu BD. (1935). Indian Medicinal Plants. In: Dehradun.

Kobori M, Yoshida M, Ohnishi-Kameyama M and Shinmoto H. (2007). Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW 264.7 macrophages and growth of HT29 colon adenocarcinoma cells. British Journal of Phamacology, 150(2):209-219.

Krishnaveni J, Rajkiran E, Manjula P and Sudheer KD. (2013). Antiurolithiatic activity of Cucumis sativus. International Journal of Pharmacological Screening Mehtods, 3(2):46-52.

Kritchevsky D. (1978). Fiber, lipids and atherosclerosis. American Journal of Clinical Nutrition, 31(10 Suppl):65-74.

Kritikar KR and Basu BD, (2006). Indian Medicinal Plants. Vol. II, International Book Distributors New Delhi. 1112-1114.

Kumar D, Kumar S, Singh J, Narender, Rashmi Vashistha BD and Singh N. (2010). Free radical scavenging and analgesic activities of Cucumis sativus L. fruit extract. Journal of Young Pharmacists, 2(4):365-368.

Liu JQ, Chen JC, Wang CF and Qiu MH. (2009). New cucurbitane triterpenoids and steroidal glycoside from Momordica charantia. Molecules, 14(12):4804-4813.

Lucky OO, John UO, Kate IE, Peter OO and Jude OE. (2012). Quantitative determination, metal analysis and antiulcer evaluation of methanol seed extract of Citrullus lanatus Thunb (Cucurbitaceae) in rats. Asian Pacific Journal of Tropical Biomedicine, 2(3):S1261-S1265.

Madhavi P, Kamala V and Habibur R. (2012). Hepatoprotective activity of C. lanatus seed oil on CCl4 induced liver damage in rats. Scholars Academic Journal of Pharmacy, 1(1):30-33.

Mallikadevi T, Paulsamy S, Karthika K and Jamuna S. (2012). In vitro and in vivo anti-inflammatory activity of whole plant methanolic extract of Mukia maderaspatana (L.) M. Roem. (Cucurbitaceae). International Journal of Pharmacy and Pharmaceutical Sciences, 4(5):435-439.

Manjusha H, Sriparna K, Sanjib B, Pallab KH, Malaya G and Upal KM. (2011). Evaluation of hypoglycemic effects of Luffa cylindrica fruit extract in rats. Journal of Advanced Pharmacy Education and Research, 2:138-146.

Menuka A, Ira T, Lakshmi A, and Handunnetti S. (2010). Anti-inflammatory activity of Trichosanthes cucumerina Linn. in rats. Journal of Ethnopharmacology, 131(3):538

Mithun VK, Amit DK and Sucheta DB. (2011). Pharmacological evaluation of ameliorative effect of aqueous extract of Cucumis sativus L. fruit formulation on wound healing in wistar rats. Chronicles of Young Scientists, Academic Journal, 2(4):207-213.

Mithun VKP, Amit DK and Sucheta DB. (2012). Effect of aqueous extract of Cucumis sativus Linn. Fruit in ulcerative colitis in laboratory animals. Asian Pacific Journal of Tropical Biomedicine, 2(2):S962-S969.

Mukerjee A, Mishra SB and Saraf S. (2014). Antihepatotoxic potential of Citrullus colocynthis root extract, fractions and isolated compounds. Journal of Pharmaceutical Technology, Research and Management, 2(2):137-143.

Mukesh T, Ashok S, Kedar Prasad S, Monit S and Kailash Y. (2011). Antioxidant and hepatoprotective activity of Trichosanthes dioica Roxb. on paracetamol induced toxicity. International Journal of Pharmaceutical Studies and Research, 2(1):110-121.

Muthumani P, Meera R, Marry S, Jeenamathew, Devi P, Kameswari B and Eswara Priya B. (2010). Phytochemcial screening and antiinflammatory, bronchodilator and antimicrobial activities of the seeds of Luffa cylindrica. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 1(4):11-22.

Nadeem S, Dhore P, Quazi M, Pawar Q and Raj N. (2012). Lagenaria siceraria fruit extract ameliorate fat amassment and serum TNF-α in high fat diet-induced obese rats. Asian Pacific Journal of Tropical Medicine, 5(9):698-702.

Nadkarni KM. (1976). Indian Materia Medica. Popular Prakashan Pvt. Ltd, Mumbai, 1:13-13.

Nadkarni AK, (1982). Indian Materia Medica. Bombay, Popular Prakashan Pvt. Ltd., Mumbai, 3:1236-1237.

Narendra Naik D, Suresh Babu VV, Sandeep Veda Narayana MS and Rangu M. (2012). In vitro screening of Corollocarpus epigaeus tuber for its analgesic, anti-pyretic and anti-inflammatory activities. International Journal of PhytoPharmacology, 3(3):241-244.

Nasrin F and Nahar L. (2014). Antidiarhoeal activity of Cucumis sativus leaves. International Journal of Phamaceutics and Drug Analysis, 2(2):106-110.

Oliveira MLMD, Nunes-Pinheiro DCS, Bezerra BMO, Leite LO, Tome AR and Girao TCC. (2013). Topical anti-inflammatory potential of pumpkin (Cucurbita pepo L.) seed oil on acute and chronic skin inflammation in mice. Acta Scientiae Veterinariae, 41:1168.

Omigie I and Agoreyo F. (2014). Effects of watermelon (Citrullus lanatus) seed on blood glucose and electrolyte parameters in diabetic wistar rats, Journal of Applied Sciences and Environmental Management, 18(2):231-233

Oragwa LN, Olajide OO, Efiom OO and Okwute SK. (2013). Didecanoate compound: isolated from Momordica charantia Linn. Seeds from Nigeria. African Journal of Pure and Applied Chemistry, 7(11):375-381.

Panda H. (1999). Herbs Cultivation and Medicinal Uses. National Institute of Industrial Re. Herb Gardens. 609.

Pandey D, Prasad SK, Sajeli Begum A, Hemalatha S and Wahi AK. (2013). Phamacognostical standardization and isolation of ergosterol from Melothria maderaspatana Linn. International Journal of Food Properties, 16(8):1871-1882.

Parameshwar H, Narsimha Reddy Y, Ravi Kumar B and Krishna Mohan G. (2010). Hepatoprotective effect of Solena amplexicaulis (tuber) on acute carbon tetrachloride induced hepatotoxicity. International Journal of Pharmacy and Technology, 2(2):375-384.

Patel S, Patel T, Parmar K, Bhatt Y, Patel Y and Patel NM. (2010). Isolation, characterization and antimicrobial activity of charantin from Momordica charantia Linn. Fruit. International Journal of Drug Development and Research, 2(3):629-634.

Pimple BP, Kadam PV and Patil MJ. (2011). Antiidiabetic and antihyperlipidemic activity of Luffa acutangula fruit extracts in streptozotocin induced NIDDM rats. Asian Journal of Pharmaceutical and Clinical Research, 4(Suppl. 2):156-163.

Pimple BP, Kadam PV and Patil MJ. (2012). Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats: Role of gastric mucosal glycoproteins and antioxidants. Asian Pacific Journal of Tropical Medicine, 5(8):610-615.

Pullaiah, T. (2006). Encyclopaedia of world medicinal plants. Regency Publications, New Delhi. 1.

Rajput MS, Mathur V, Agrawal P, Chandrawanshi HK and Pilaniya U. (2011). Fibrinolytic activity of Kaempferol isolated from the fruits of Lagenaria siceraria (Molina) Standley. Natural Products Research, 25(19):1870-1875.

Ramakrishnan M, Bhuvaneshwari R, Druraipandiyan V and Dhandapani R. (2011). Hypoglycemic activity of Coccinia indica Wight and Arn. Fruits in alloxan-induced diabetic rats. Indian Journal of Natural Products and Resources, 2(3):350-353.

Ramzi AM, Nawal MAM, Mohamed FAA, Paul C and Louis M. (2014). Evaluation of the in vitro antiplasmodial, antileishmanial and antitrypanosomal activity of medicinal plants used in Saudi and Yemeni traditional medicine. Evidence-Based Complementary and Alternative Medicine, Article ID 905639, 7.

Revathi P. and T. Parimelazhagan. (2010). Traditional knowledge on medicinal plants used by the Irula tribe of Hasanur hills, Erode district, Tamil Nadu, India. Ethnobotanical Leaflets, 14:136-160.

Ríos-Silva M, Trujillo X, Trujillo-Hernández B, Sánchez-Pastor E, Urzúa Z, Mancilla E and Huerta M. (2014). Effect of Chronic Administration of Forskolin on Glycemia and Oxidative Stress in Rats with and without Experimental Diabetes. International Journal of Medical Sciences, 11(5):448–452.

Rudrapratap K, Monika P, Laxmi L, Neelang T and Bhawana C. (2013). Evaluation of anti-inflammatory activity of methanol extract of Coccinia indica (Cucurbitaceae) fruit. American Journal of Pharm Tech Research, 3(1):905-912.

Saha P, Mazumder UK and Haldar PK. (2015). Evaluation of antininflammatory and antinociceptive properties of Lagenaria siceraria aerial parts. International Journal of Pharma Sciences and Research, 6(5):874-881.

Sakthi Abirami M, Indhumathy R, Sashikala Devi G, Satheesh Kumar D, Sudarvoli M and Nandini. (2011). Evaluation of the wound healing and antiinflammatory activity of whole plant of Luffa cylindrica (Linn.) in rats. Pharmacology online, 3:281-285.

Sandhya S, Chandrasekhar J, Vinod KR and David B. (2012). Potentiality of aqueous leaf extract of Trichosanthes cucumerina Linn. on hair growth promotion in Wistar albino rats. Indian Journal of Natural Products and Resources, 3(1):14-19.

Sanjib B, Angelene P and Pallab KH, (2011). Evaluation of antiproliferative activity of Trichosanthes dioica root against ehrlich ascities carcinoma cells. Academic Journal of Cancer Research, 4(2):38-42.

Saravanan VS and Manokaran S. (2012). Anti-anaemic activity of some plants in Cucurbitaceae on phenylhydrazine-induced anaemic rats. The Thai Journal of Pharmaceutical Sciemces, 36(4):150-154.

Sarkar S and Buha D. (2008). Effect of ripe fruit pulp extract of Cucurbita pepo Linn. In aspirin induced gastric and duodenal ulcer in rats. Indian Journal of Experimental Biology, 46(9):639-645.

Sathesh Kumar S, Ravi Kumar B and Krishna Mohan G. (2009). Hepatoprotective effect of Trichosanthes cucumerina Var cucumerina L. on carbon tetrachloride induced liver damage in rats. Journal of Ethnopharmacology, 123(2):347-350.

Sezik E, Yesilada E, Shadidoyatov H, Kulivey Z, Nigmatullaev AM, Aripov HN, Takaishi Y, Takeda Y and Honda G. (2004). Folk medicine in Uzbekistan I Toshkent, Djizzax, and Samarqand Provinces. Journal of Ethnopharmacology, 92(2-3):197.

Shalini A, Bairy KK, Meharban A and Punita ISR. (2010). Hypoglycemic effect of aqueous extract of Trichosanthes dioica in normal and diabetic rats. International Journal of Diabetic Dev Ctries, 30(1):38-42.

Sharma D, Rawat I and Goel HC. (2015). Anticancer and anti-inflammatory activities of some dietary cucurbits. Indian Journal of Experimental Biology, 53:216-221.

Sharma NK, Priyanka Kishore Jha K, Kumar Singh H and Shrivastava AK. (2014). Hepatoprotective activity of Luffa cylindrica (L.) M.J. Roem. leaf extract in paracetamol intoxicated rats. Indian Journal of Natural Products and Resources, 5(2):143-148.

Shawkey AM, Rabeh MA, Abdulall AK and Abdellatif AO. (2013). Green nanotechnology: Anticancer Activity of Silver Nanoparticles using Citrullus colocynthis aqueous extracts. Advances in Life Science and Technology, 13:60-70.

Shivaji PG and Chandrashekar RMV. (2012). Antiheptotoxic activities of Ci compound: β-sitosterol isolated from fruits and leaves of Coccinia indica. Indian Journal of Pharmaceutical Education and Research, 46(1):4-8

Siddig IA, Loiy Elsir AH, Hasnah MS, Sakina MAY, Waleed SK, Syam M, Manal MET, Syahida A, Cheah SC, Putri N, Moud MR and Hamid AH. (2011). Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: Role of reactive nitrogen species and cyclooxygenase enzyme inhibition. Fitoterapia, 82(8):1190-1197.

Song F, Dai B, Zhang HY, Xie JW, Gu CZ and Zhang J. (2015). Two new cucurbitane-type triterpenoid saponins isolated from ethylacetate extract of Citrullus colocynthis fruit. Journal of Asian Natural Products Research, 11:1-6.

Souza NJ, Dohadwalla AN and Reden J. (1983). Forskolin: a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties. Medicinal Research Reviews, 3(2):201-219.

Srivastava G, Jain R, Vyas N, Mehta A, Kachhwaha S and Kothari SL. (2013). Antimicrobial activity of the methanolic extract, fractions and isolated compounds from Citrullus colocynthis (L.) Schrad. International Journal of Pharma and Biosciences, 4(3):825-833.

Stephens J.M. (2003). Gourd Luffa: Luffa cylindrica, Luffa aegyptica, Luffa acutangula. Journal of Horticultural Sciences, 3:19-21.

Sudhanshu Kumar B, Amit K, Neeraj Kumar S, Prakash O, Sudhir Kumar J, Supriya K, Ashok Kumar G and Awanish K. (2013). Tocopheral from seeds of cucurbita pepo against diabetes: validation by in vivo experiments supported by computational docking. Journal of The Formation Medical Association, 112(11):676-690.

Takaku T, Yoshiyuki K and Okuda H. (2001). Isolation of an anti-tumor compound from Agaricus blazei Murill and its mechanism of action. JN The Journal of Nutrition, 131(5):1409-1413.

Tan MJ, Ye JM, Turner N, Hohnen-Behrens C, Ke CQ, Tang CP, Chen T, Weiss HC, Gesing ER, Rowland A, James DE and Ye Y. (2008). Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chemistry and Biology, 15(3):263-273.

Tang J, Meng X, Liu H, Zhao J, Zhou L, Qiu M, Zhang X, Yu Z and Yang F. (2010). Antimicrobial activity of sphingolipids isolated from the stems of cucumber (Cucumis sativus L.). Molecules, 15(12):9288-9297.

Vaidya LS, (1953). Shaligram Nighantu Bhushanam, (Khemraj Srikrishnada, Steam Press, Mumbai). p. 891.

Vanajothi R and Srinivasan P. (2014). Bioassay-guided isolation and identification of bioactive compound from aerial parts of Luffa acutangula against lung cancer cell line NCI-H460. Journal of Recept Signal Transduct Research, 12:1-8.

Vetriselvan S, Subasini U, Velmurugan C, Muthuramu T, Shankar J and Revathy. (2013). Anti- inflammatory activity of Cucumis sativus seed in carrageenan and xylene induced edema model using albino wistar rats. International Journal of Biopharmaceutics, 4(1):34-37.

Vishal BJ, Vishnu JT, Anupama AS and Suresh RN. (2013). Ameliorative effect of Luffa acutangula Roxb. On doxorubicin induced cardiac and nephrotoxicity in mice. Indian Journal of Experimental Biology, 51(2):149-156.

Viyaya Kirubha TS, Senthamarai R, Vasuki K, Venkateswara Rao A and Selvadurai S. (2011). Anthelmintic activity of roots and rhizomes of Corallocarpus epigaeus. Journal of Natural Products Plant Resources, 1(1):81-84.

Xiong SL, Fang ZP and Zeng XY. (1994). Chemical constituents of Luffa cylindrical (L.) Roem. Zhongguo Zhong Yao Za Zhi, 19(4):233-234.

Copyright license for the research articles published in Journal of Research in Biology are as per the license given below

Creative Commons License
Journal of Research in Ecology is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0). (www.creativecommons.org)
Based on a work at www.jresearchbiology.com
What this License explains us?

You are free to:

Share — copy and redistribute the material in any medium or format

Adapt — remix, transform, and build upon the material

for any purpose, even commercially.

This license is acceptable for Free Cultural Works. The licensor cannot revoke these freedoms as long as you follow the license terms.

[As given in the www.creativecommons.org website]

Under the following terms:

Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.