Keywords
Justicia gendarussa
Patentiflorin-A
Anticancer
Antibiotic
Cardioprotective and PASS
Patentiflorin-A
Anticancer
Antibiotic
Cardioprotective and PASS
How to Cite
D, A. C., P, J. S., & R, M. (2019). In-silico analysis of Patentiflorin A – a potent drug from Justicia gendarussa. Journal of Research in Biology, 9(8), 2769 -2779. Retrieved from https://ojs.jresearchbiology.com/index.php/jrb/article/view/506
Abstract
Justicia gendarussa is a highly valuable ethno medicinal plant. Due to the identification of the novel chemical constituent Patentiflorin - A, it has been more popularized for the treatment of HIV-AIDS. This potent drug has been analyzed using in-silico tools and servers for understanding its therapeutic nature. In this analysis, we found that it is used to treat a variety of ailments including cancer, rheumatism, allergy, Alzheimer's disease, Parkinson’s disease, Gaucher disease, Charcot-Marie-tooth disease, common cold, liver disease and cardiac arrest etc., This research is fruitful as most of its hidden uses are understood.
References
Agastian P, Williams L and Ignacimuthu S. 2006. In vitro propagation of Justicia gendarussa Burm. f. - A medicinal plant. Indian Journal of Biotechnology, 5(2): 246-248.
Chopra RN, Nayar SL and Chopra IC. 1986. Glossary of Indian Medicinal Plants (Including the Supplement). Council of scientific and industrial research, New Delhi. Very terse details of medicinal uses of plants with a wide range of references and details of research into the plants chemistry. Not for the casual reader.
Coconuts Jakarta [Internet] Indonesia is about to start producing a male birth control pill that will change the world. 2015 [cited 2014 November 24].
Computer Aided Drug Design in Industrial Research (Ernst Schering Foundation Symposium Proceedings Book 15) 1st Edition, Kindle Edition, Springer; 1 edition (March 9, 2013), 274 P.
Dennis TT and Hoshino Y. 2010. In vitro propagation for the conservation of a rare medicinal plant Justicia gendarussa Burm. f. by nodal explants and shoot regeneration from callus. Acta Physiologiae Plantarum, 32: 943-950.
Duke JA and Ayensu ES. 1985. Medicinal plants of China. 2nd Volume, Reference publications, Inc. Algonac. Michigan, 398 P.
Filimonov DA and Poroikov VV. 1996. PASS computerized prediction of biological activity spectra for chemical substances, bioactive compound design: possibilities for industrial use. BIOS Scientific Publishers, Oxford, 47-56 P.
Filimonov DA, Poroikov VV, Karaicheva, EI, Kazarian RK, Budunova AP, Mikhailovskii, EM, Rudnitskih AV, Goncharenko LV and Burov YV. 1995. The computerized prediction of the spectrum of biological activity of chemical compounds by their structural formula: the pass system. Prediction of activity spectra for substance. Experimental and Clinical Pharmacology (Rus), 58(2): 56-62.
Filimonov DA, Trapkov VA, Boudunova AP, Burova OA and Poroikov VV. 1996. Discovery of new chemical entry with antiulcer activity by using computer aided prediction. Abstract XIVth International Symposium on Medicinal Chemistry, Maastricht, the Netherlands, 1-12 P.
Garporova R, Lacova M, El-Shaaer HM and Odlerova Z. 1997. Synthesis and antimycobacterial activity of some new 3-heterocyclic substituted chromones, Il Farmaco, 52(4) 251-253.
Hong-Jie Z, Emily RB, Yi-Fu G, Dong-Ying W, Kang-Lun L, Wan-Fei L, Van HN, Nguyen MC, Djaja DS, Harry HSF and Lijun R. 2017. Potent inhibitor of drug-resistant HIV-1 strains identified from the medicinal plant Justicia gendarussa. Journal of Natural Products, 80(6): 1798-1807.
Hu-Nan C and I Yao YCS. 1978. A barefoot doctors manual. Running Press ISBN 0-914294-92-X. A very readable herbal from China, combining some modern methods with traditional Chinese methods.
Margita L, Dusan Loos, Mikulas Furdik, Maria Matulova and Hafez M. El-Shaaer. 1998. Synthesis and reactions of new 4-Oxo-4H-benzopyran-3-carboxaldehydes containing hydroxy groups or 2-oxopyran cycles. Molecules, 3(6): 149-158.
National Center for Biotechnology Information [Internet] [NCBI] PubChem Database. Patentiflorin A, CID=11785812: 2006 [cited 2019 Aug 28]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Patentiflorin-A
Nizamuddin, Mishra M, Srivastava MK and Khan MH. 2001. Synthesis and fungicidal activity of 3,6,9-triaryl-2-thioxothiazolo[ 4,5-d][1,3,4] oxadiazolo [2,3-b]pyrimidine and 3,10-diaryl-2-thioxothiazolo[ 4,5-d]pyrimido [2,1-b] pyrimidines, Indian Journal of Chemistry, 40B: 49-53.
Nohara A, Umetani T and Sanno Y. 1973. A facile synthesis of chromone-3-carboxaldehyde, chromone-3-carboxylic acid and 3-hydroxymethylchromone, Tetrahedron Letters, 14(22): 1995-1998.
Nohara A, Umetani T and Sanno Y. 1974. Studies on antianaphylactic agents-I: A facile synthesis of 4-oxo-4H-1-benzopyran-3-carboxaldehydes by Vilsmeier reagents Tetrahedron, 30(19): 3553-3561.
Paval J, Kaitheri SK, Potu BK, Govindan S, Kumar RS, Narayanan SN and Moorkoth S. 2009. Anti-arthritic potential of the plant Justicia gendarussa Burm F. Clinics, 64(4): 357-362.
PBS News Hour [Internet] [PBS] Indonesian Plant Shows Promise for Male Birth Control. 2011: [cited Sep 06]. Available from: https://www.tpt.org/pbs-newshour/video/pbs-newshour-indonesian-plant-shows-promise-as-male-birth-control/
Plant resources of South-East Asia. [Internet]. [Prosea] Prosea association prevents extinction of rare plants in southeast Asia. [cited 2019 Sep 04]. Available from:=http://proseanet.org/prosea/news_details.php?id=13
Proudfoot JR. 2002. Drugs, leads, and drug-likeness: an analysis of some recently launched drugs. Bioorganic and Medicinal Chemistry Letters, 12(12):1647-1650.
Reynolds GA and Van Allan JA. 1969. The reactions of 2,2-difluoro-4-methylnaphtho[l,2-e]-1,3,2-dioxaborin and its [2,1-e]isomer with N,N-dimethylformamide, Journal of Heterocyclic Chemistry, 6(3): 375-377.
Salama MA and El-Essa SA. 2001. Synthesis and reactions of some new substituted phenylhydrazono ideno-thiazolo [3,2-b] pyrimidin-3-ones of possible antimicrobial activity, Indian Journal of Chemistry, 40B(08): 678-689.
Sandoiu A. 2017. Plant compound 'much more effective' than traditional anti-HIV drug. Medical news today.
Sawatzky DA, Willoughby DA, Colville-Nash PR, Rossi AG. 2006. The involvement of the apoptosis-modulating proteins Erk 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo. The American Journal of Pathology, 168(1): 33-41.
Sridhar C, Krishnaraju AV and Subbaraju GV. 2006. Antiinflammatory constituents of teramnus labialis. Indian Journal of Pharmaceutical Sciences, 68(1): 111-114.
Suja S, Su Yeon Hwang, Keun-Hyeung Lee and Hyeong-jin Cho. 2005. Synthesis of Formylchromone Derivatives; Inactivators of Protein Tyrosine Phosphatase 1B, Bulletin- Korean Chemical Society, 26(7): 1138-1140.
The World from PRX [Internet] [GlobalPost]. Indonesia's birth control pill for men: 2011. [cited 2019 Aug 27]. Available from: https://www.pri.org/stories/2011-02-27/indonesias-birth-control-pill-men
University of Illinois at Chicago. 2017. Plant compound more powerful than AZT against HIV." Science Daily. Science Daily.
Verma A. 2012. Lead finding from Phyllanthus debelis with hepatoprotective potentials. Asian Pacific Journal of Tropical Biomedicine, 2(3): S1735-S1737.
Wahi SP, Wahi AK and Kapoor R. 1974. Chemical study of the leaf of Justicia gendarussa Burm. JRIM. 9: 65-66.
William D, Warden CJH and David H. 1893. Pharmacographia Indica: History of the principal drugs of vegetable drugs. Bombay at the Education Society‟s Press, 642 P.
Chopra RN, Nayar SL and Chopra IC. 1986. Glossary of Indian Medicinal Plants (Including the Supplement). Council of scientific and industrial research, New Delhi. Very terse details of medicinal uses of plants with a wide range of references and details of research into the plants chemistry. Not for the casual reader.
Coconuts Jakarta [Internet] Indonesia is about to start producing a male birth control pill that will change the world. 2015 [cited 2014 November 24].
Computer Aided Drug Design in Industrial Research (Ernst Schering Foundation Symposium Proceedings Book 15) 1st Edition, Kindle Edition, Springer; 1 edition (March 9, 2013), 274 P.
Dennis TT and Hoshino Y. 2010. In vitro propagation for the conservation of a rare medicinal plant Justicia gendarussa Burm. f. by nodal explants and shoot regeneration from callus. Acta Physiologiae Plantarum, 32: 943-950.
Duke JA and Ayensu ES. 1985. Medicinal plants of China. 2nd Volume, Reference publications, Inc. Algonac. Michigan, 398 P.
Filimonov DA and Poroikov VV. 1996. PASS computerized prediction of biological activity spectra for chemical substances, bioactive compound design: possibilities for industrial use. BIOS Scientific Publishers, Oxford, 47-56 P.
Filimonov DA, Poroikov VV, Karaicheva, EI, Kazarian RK, Budunova AP, Mikhailovskii, EM, Rudnitskih AV, Goncharenko LV and Burov YV. 1995. The computerized prediction of the spectrum of biological activity of chemical compounds by their structural formula: the pass system. Prediction of activity spectra for substance. Experimental and Clinical Pharmacology (Rus), 58(2): 56-62.
Filimonov DA, Trapkov VA, Boudunova AP, Burova OA and Poroikov VV. 1996. Discovery of new chemical entry with antiulcer activity by using computer aided prediction. Abstract XIVth International Symposium on Medicinal Chemistry, Maastricht, the Netherlands, 1-12 P.
Garporova R, Lacova M, El-Shaaer HM and Odlerova Z. 1997. Synthesis and antimycobacterial activity of some new 3-heterocyclic substituted chromones, Il Farmaco, 52(4) 251-253.
Hong-Jie Z, Emily RB, Yi-Fu G, Dong-Ying W, Kang-Lun L, Wan-Fei L, Van HN, Nguyen MC, Djaja DS, Harry HSF and Lijun R. 2017. Potent inhibitor of drug-resistant HIV-1 strains identified from the medicinal plant Justicia gendarussa. Journal of Natural Products, 80(6): 1798-1807.
Hu-Nan C and I Yao YCS. 1978. A barefoot doctors manual. Running Press ISBN 0-914294-92-X. A very readable herbal from China, combining some modern methods with traditional Chinese methods.
Margita L, Dusan Loos, Mikulas Furdik, Maria Matulova and Hafez M. El-Shaaer. 1998. Synthesis and reactions of new 4-Oxo-4H-benzopyran-3-carboxaldehydes containing hydroxy groups or 2-oxopyran cycles. Molecules, 3(6): 149-158.
National Center for Biotechnology Information [Internet] [NCBI] PubChem Database. Patentiflorin A, CID=11785812: 2006 [cited 2019 Aug 28]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Patentiflorin-A
Nizamuddin, Mishra M, Srivastava MK and Khan MH. 2001. Synthesis and fungicidal activity of 3,6,9-triaryl-2-thioxothiazolo[ 4,5-d][1,3,4] oxadiazolo [2,3-b]pyrimidine and 3,10-diaryl-2-thioxothiazolo[ 4,5-d]pyrimido [2,1-b] pyrimidines, Indian Journal of Chemistry, 40B: 49-53.
Nohara A, Umetani T and Sanno Y. 1973. A facile synthesis of chromone-3-carboxaldehyde, chromone-3-carboxylic acid and 3-hydroxymethylchromone, Tetrahedron Letters, 14(22): 1995-1998.
Nohara A, Umetani T and Sanno Y. 1974. Studies on antianaphylactic agents-I: A facile synthesis of 4-oxo-4H-1-benzopyran-3-carboxaldehydes by Vilsmeier reagents Tetrahedron, 30(19): 3553-3561.
Paval J, Kaitheri SK, Potu BK, Govindan S, Kumar RS, Narayanan SN and Moorkoth S. 2009. Anti-arthritic potential of the plant Justicia gendarussa Burm F. Clinics, 64(4): 357-362.
PBS News Hour [Internet] [PBS] Indonesian Plant Shows Promise for Male Birth Control. 2011: [cited Sep 06]. Available from: https://www.tpt.org/pbs-newshour/video/pbs-newshour-indonesian-plant-shows-promise-as-male-birth-control/
Plant resources of South-East Asia. [Internet]. [Prosea] Prosea association prevents extinction of rare plants in southeast Asia. [cited 2019 Sep 04]. Available from:=http://proseanet.org/prosea/news_details.php?id=13
Proudfoot JR. 2002. Drugs, leads, and drug-likeness: an analysis of some recently launched drugs. Bioorganic and Medicinal Chemistry Letters, 12(12):1647-1650.
Reynolds GA and Van Allan JA. 1969. The reactions of 2,2-difluoro-4-methylnaphtho[l,2-e]-1,3,2-dioxaborin and its [2,1-e]isomer with N,N-dimethylformamide, Journal of Heterocyclic Chemistry, 6(3): 375-377.
Salama MA and El-Essa SA. 2001. Synthesis and reactions of some new substituted phenylhydrazono ideno-thiazolo [3,2-b] pyrimidin-3-ones of possible antimicrobial activity, Indian Journal of Chemistry, 40B(08): 678-689.
Sandoiu A. 2017. Plant compound 'much more effective' than traditional anti-HIV drug. Medical news today.
Sawatzky DA, Willoughby DA, Colville-Nash PR, Rossi AG. 2006. The involvement of the apoptosis-modulating proteins Erk 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo. The American Journal of Pathology, 168(1): 33-41.
Sridhar C, Krishnaraju AV and Subbaraju GV. 2006. Antiinflammatory constituents of teramnus labialis. Indian Journal of Pharmaceutical Sciences, 68(1): 111-114.
Suja S, Su Yeon Hwang, Keun-Hyeung Lee and Hyeong-jin Cho. 2005. Synthesis of Formylchromone Derivatives; Inactivators of Protein Tyrosine Phosphatase 1B, Bulletin- Korean Chemical Society, 26(7): 1138-1140.
The World from PRX [Internet] [GlobalPost]. Indonesia's birth control pill for men: 2011. [cited 2019 Aug 27]. Available from: https://www.pri.org/stories/2011-02-27/indonesias-birth-control-pill-men
University of Illinois at Chicago. 2017. Plant compound more powerful than AZT against HIV." Science Daily. Science Daily.
Verma A. 2012. Lead finding from Phyllanthus debelis with hepatoprotective potentials. Asian Pacific Journal of Tropical Biomedicine, 2(3): S1735-S1737.
Wahi SP, Wahi AK and Kapoor R. 1974. Chemical study of the leaf of Justicia gendarussa Burm. JRIM. 9: 65-66.
William D, Warden CJH and David H. 1893. Pharmacographia Indica: History of the principal drugs of vegetable drugs. Bombay at the Education Society‟s Press, 642 P.
Copyright license for the research articles published in Journal of Research in Biology are as per the license given below
Creative Commons License
Journal of Research in Ecology is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0). (www.creativecommons.org)
Based on a work at www.jresearchbiology.com
What this License explains us?
You are free to:
Share — copy and redistribute the material in any medium or format
Adapt — remix, transform, and build upon the material
for any purpose, even commercially.
This license is acceptable for Free Cultural Works. The licensor cannot revoke these freedoms as long as you follow the license terms.
[As given in the www.creativecommons.org website]
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.