Exercise, Training and Gut Function – a Physiological Perspective
Abstract
Gastrointestinal (GI) tract adapts and cope with demands of the physical activity to exert maximum output in an athlete. Various GI functions, e.g., secretion, motility, circulation, emptying pattern, absorption, colonic function, etc., undergoes various alterations not only during the event but also during the warranted demand of the training and recovery phases. It depends on the duration, intensity and frequency of the exercise mode. However, often the GI responses to exercise are individual specific. Hyperthermia induced gastric dysfunction have also been documented. Accordingly the adaptations are also evident in the gut depending on the athletic need. However, the gut barrier can prevent the extreme load on the GI tract imposed during working in the excessive stressed conditions
References
American College of Sport Medicine. 2006. ACM’s guidelines for exercise testing and prescription. 7th edition. Philadelphia: Lippincott Williams & Wilkins.
Boley SJ, Brandt LJ, Frank MS. 1981. Severe lower intestinal bleeding: diagnosis and treatment. Clin Gastroenterol 10:65.
Brouns F. 1998. Gastric emptying as a regulatory factor in fluid uptake. Int J Sports Med., 19:S125-S128.
Brouns F and E Beckers. 1993. Is the gut an athletic organ? Digestion, absorption and exercise. Sports Med., 15:242-257.
Carrio I, Estorch M, Serra-Grima R, Ginjaume M, Notivol R, Calabuig R, and Vilardell F. 1989. Gastric emptying in marathon runners. Gut 30:152–155.
Chang FY, Lu CL, Lee SD, Doong ML, Yeh JY, Wang PS. 2006. Interaction of carbohydrate metabolism and rat liquid gastric emptying in sustained running. J Gastroenterol Hepatol., 21:831-836.
Eichner ER. 1999. Gut reactions: athletes’ gastrointestinal problems. Sports Med Digest October 111–112.
Fink MPKL, Kaups H, Wang L, Rothschild HR.1991. Maintenance of superior mesenteric arterial perfusion prevents increased intestinal mucosal permeability in endotoxic pigs. Surgery 54:31-36.
Fordtran JS, Saltin B. 1967. Gastric emptying and intestinal absorption during prolonged severe exercise. J Appl Physiol 23:331-335.
Gisolfi CV. 2000. Is the GI system built for exercise? News Physiol Sci 15:114-119.
Gisolfi CVKJ, Spranger RW, Summers HP, Schedle HP, Bleiler TI. 1991. Effects of cyclic exercise on intestinal absorption in humans. J Appl Physiol., 71:2518-2527.
Hall DM, Buettner GR, Matthes RD, and Gisolfi CV. 1994. Hyperthermia stimulates nitric oxide formation: electron paramagnetic resonance detection of NO-heme in blood. J Appl Physiol., 77:548-553.
Harris A, Lindeman AK, Martin BJ. 1991. Rapid orocecal transit in chronically active persons with high energy intake. J Appl Physiol., 70:1550-1553.
Johannesson E, Simrén M, Strid H, Bajor A, Sadik R. 2011. Physical activity improves symptoms in irritable bowel syndrome: a randomized controlled trial. Am J Gastroenterol 106:915-922.
Lambert GP, Chang RT, Joensen D, Shi X, Summers RW, Schedl HP, and Gisolfi CV. 1996. Simultaneous determination of gastric emptying and intestinal absorption during cycle exercise in humans. Int J Sports Med., 17:48-55.
Lambert GP, Chang RT, Xia T, Summers RW and Gisolfi CV. 1997. Absorption from different intestinal segments during exercise. J. Appl.Physiol., 83:204-212.
Leiper JB, Nicholas CW, Ali A. 2005. The effect of intermittent high-intensity running on gastric emptying of fluids in man. Med Sci Sports Exerc., 37:240-247.
Madara JL and Stafford J. 1989. Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest 83:724-727.
Marzio L, Formica P, Fabiani F, LaPenna D, Vecchiett L, Cuccurullo F. 1991. Influence of physical activity on gastric emptying of liquids in normal human subjects. Am J Gastroenterol 86:1433-1436.
Michiel A. 2004. Van Nieuwenhoven Æ Fred Brouns Robert-Jan M. Brummer. Gastrointestinal profile of symptomatic athletes at rest and during physical exerciseEur J Appl Physiol., 91:429-434
Morton DP, Callister R. 2000. Characteristics and etiology of exercise-related transient abdominal pain. Med Sci Sports Exerc., 32:432-438.
Moses FM. 1993. Gastrointestinal bleeding and the athlete. Am J Gastroenterol 88:1157-1159.
Moses FM. 1990. The effect of exercise on gastrointestinal tract. Sports Med., 9:159-172.
Murray R and Kenney WL. 2008. Sodium balance and exercise. Current Sport Med Rep., 7:S1-S2.
Murray R, Shi X. 2005. The gastrointestinal system. In ACSM’s Advanced Exercise Physiology. Edited by Tipton CM, Sawka MN, Tate CA, Terjung RL. Philadelphia: Lippincott Williams &Wilkins 357-369.
Murray R. 2006. Training the gut for competition. Curr Sport Med Rep 5:161-164.
Neufer PD, Young AJ and Sawka MN. 1989. Gastric emptying during exercise: effects of heat stress and hypohydration. Eur J Appl Physiol., 58:433-439.
Peters HP, Bos M, Seebregts L, Akkermans LM, van Berge Henegouwen GP, Bol E, Mosterd WL, De Vries WR. 1999. Gastrointestinal symptoms in long-distance runners, cyclists, and triathletes: prevalence, medication, and etiology. Am J Gastroenterol 94:1570-1581.
Rao SSC, Beaty J, Chamberlain M. 1999. Effects of acute graded exercise on human colonic motility. Am J Physiol (Gastrointest Liver Physiol) 276:G1221-G1226.
Rehrer NJ, Beckers EJ, Brouns F, Hoor FT, and Saris WH. Effects of dehydration on gastric emptying and gastrointestinal distress while running. Med Sci Sports Exerc 1990; 22: 790–795.
Rehrer NJ, Van Kemenade MC, Meester TA. 1992. Gastrointestinal complaints in relation to dietary intakes in triathletes. Int J Sports Nutr., 2:48 -59.
Rehrer NJ, Wagenmakers AJ, Beckers, Halliday D, Leiper DB, Brouns F, Maughan RJ, Westerterp K, and Saris WH. 1992. Gastric emptying, absorption, and carbohydrate oxidation during prolonged exercise. J Appl Physiol., 72:468-475.
Sakurada S and Hales JRS. 1998. A role for gastrointestinal endotoxins in enhancement of heat tolerance by physical fitness. J Appl Physiol., 84:207-2148.
Sawka MN, Young AJ. 2005. Physiological systems and their responses to conditions of heat and cold. In ACSM’s Advanced Exercise Physiology. Edited by Tipton CM, Sawka MN, Tate CA, Terjung RL. Philadelphia: Lippincott Williams & Wilkins 535-563.
Schwartz AE, Vanagunas A, and Kamel PL. 1990. Endoscopy to evaluate gastrointestinal bleeding in marathon runners. Ann Int Med., 113:632-633.
Shi X, Horn MK, Osterberg KO. 2004. Gastrointestinal discomfort during intermittent high -intensity exercise: effect of carbohydrateelectrolyte beverage. Int J Sports Nutr Exerc Metab., 14:673-683.
Shi XR, Summers W, Schedl HP, Chang RT, Lambert GP, and Gisolfi CV. 1994. Effects of solution osmolality on absorption of select fluid replacement solutions in human duodenojejunum. J Appl Physiol., 77:1178-1184.
Soffer EE, Merchant RK, Duethman G, Launspach J, Gisolfi C, and Adrian TE. 1993. Effect of graded exercise on esophageal motility and gastroesophageal reflux in trained athletes. Dig Dis Sci 38:220-224.
Valdés-Ramos R, Martínez-Carrillo BE, ArandaGonzález II, Guadarrama AL, Pardo-Morales RV, Tlatempa P, Jarillo-Luna RA. 2010. Diet, exercise and gut mucosal immunity. Proc Nutr Soc., 69:644-50.
Van Nieuwenhoven MA, Brouns F, Brummer RJ. 2004. Gastric emptying showed no differences between rest, cycling and running. Eur J Appl Physiol., 91:429-434.
Van Nieuwenhoven MA, Vriens BEPJ, Brummer RJM, Brouns F. 2000. Effect of dehydration on gastrointestinal function at rest and during exercise in humans. Eur J Appl Physiol., 83:578-584