Probiotics - A broad spectrum therapy
Abstract
“Probiotics” are the living microorganisms which are healthful to the human population. In recent years, these probiotics are being universally used in the doctoring of broad range of human diseases, conditions and syndromes. Various researches and clinical trials have been carried out for the proper annotation of the mechanisms and their mode of action which they exert on human health. Strong evidences substantiate the efficient use of probiotics in the treatment and prevention of Candidiasis, hypercholesterolemia, diarrhoea, dermatitis and several other diseases. The probiotic agents which are most commonly used are lactobacillus, bifidobacterium, and yeast. In this review, detailed overview of the use of these probiotic agents were done for curing several ailments with manifestations of clinical trials. In future, probiotics could be used as a remedy for colon and bladder cancer, diabetes, and rheumotoid arthiritis
References
Allen SJ, Okoko B, Martinez E, Gregorio G, Dans LF. 2003. Probiotics fortreating infectious diarrhea. Cochrane Database Syst Rev., 2:CD003048.
Aso Y, Akaza H, Kotake T. 1992. Prophylactic effect of a Lactobacillus casei preparation on the recurrence of superficial bladder cancer. Urol Int., 49:125-9.
Bengmark S. 1998. Ecological control of the gastrointestinal tract: the role of probiotic flora. Gut 42:2-7.
Bin LX. 1995. Étude contrôlée du Lactéol Fort sachets versus furazolidoneou berbérine dans le traitement des diarrhées aiguës de l‟enfant. (Controlled clinical trial in infants and children comparingLacteol Fort sachets with two antidiarrheal reference drugs.) AnnPediatr (Paris) 42:396-401 (in French).
Blum S, Reniero R, Schiffrin EJ. 1999. Adhesion studies for probiotics: need for validation and refinement. Trends Food Sci Technol., 10:405-10.
Caetano JA, Parames MT, Babo MY. 1986. Immunopharmacologicaleffects of Saccharomyces boulardii in healthy volunteers. Int J Immunopharmacol., 8:245-59.
Cetina-Sauri G, Sierra Basto G. 1994. Evaluation therapeutique de Saccharomycesboulardii chez des enfants souffrant de diarrhee aigue. Ann. Pediatr., 41:397-400.
D’Souza AL, Rajkumar C, Cooke J, Bulpitt CJ. 2002. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ 324:1361. Allen SJ, Okoko B, Martinez E, Gregorio G, Dans LF. Probiotics for treating infectious diarrhea. Cochrane Database Syst Rev 2003CD003048.
Elmer GW, Surawicz CM, McFarland LV. 1996. Biotherapeutic agents. A neglected modality for the treatment and prevention of selected intestinal and vaginal infections. JAMA 275:870-6.
Eschenbach DA, Davick BL, Williams SJ. 1989. Prevalence of hydrogenperoxidase producing Lactobacillus species in normal women andwomen with bacterial vaginosis. J Clin. Microbiol., 27:251-6.
Falagas ME, Betsi GI, Athanasiou S. 2006. Probiotics for Prevention of Recurrent Vulvovaginal Candidiasis: A Review. J. Antimicrob. Chemother., 58:266-272.
FAO/WHO. 2002. Guidelines for the evaluation of probiotics in food. Internet: http://www.who.int/foodsafety/fs_management/en/probiotic_guidelines.pdf (accessed 22 March 2006). Fuller.R. Probiotics in Human medicine. Gut., 191:32:432-42.
Foxman B, Barlow R, D'Arcy H, Gillespie B, Sobel JD. 2000. Candida vaginitis: self-reported incidence and associated costs. Amer. Sex. Transm. Dis. Assoc., 27:230-235.
Galdeano CM, de LeBlanc A, de M, Vinderola G, Bonet MEB, Perdigón G. 2007. Proposed Model: Mechanismsof Immunomodulation Induced by Probiotic Bacteria. Clin. Vaccine Immunol., 14:485-492.
Gill HS, Cross ML. 2001. Probiotics and immune function. In: Calder PC, Field CJ, Gill HS, eds. Nutrition and immunity. Wallingford, UK: CABI International 251-72.
Gilliland SE, Nelson CR, Maxwell C. 1985. Assimilation of cholesterol byLactobacillus acidophilus. Appl Environ Microbiol., 49:377-81.
Gilliland SE, Noh DO. 1989. Influence of bile salts on b-galactosidaseactivity and cellular integrity of Lactobacillus acidophilus. AnimalSci Res Rep., 257.
Gilliland SE, Walker DK. 1989. Cholesterol uptake by culture of Lactobacillus acidophilus used for nonfermented acidophilus milk. AnimSci Res Rep., 258-62.
Gorbach SL. 2000. Probiotics and gastrointestinal health. Am J Gastroentero l95(Suppl): S2-S4.
Guandalini S, Pensabene L, Zikri MA. 2000. Lactobacillus GG administeredin oral rehydration solution to children with acute diarrhea: amulticenter European trial. J Pediatr Gastroenterol Nutr., 30:54-60.
Hessle C, Hanson LA, Wold AE. 1999. Lactobacilli from human gastrointestinalmucosa are strong stimulators of Il-12 production. Clin ExpImmunol., 116:276-82.
Hillier S. 1998. The vaginal microbial ecosystem and resistance to HIV. AIDSRes Hum Retroviruses 14 (Suppl 1):S17-S21.
Hilton E, Isenberg HD, Alperstein P. 1992. Ingestion of yogurt containingLactobacillus acidophilus as prophylaxis for candidal vaginitis.Ann Intern Med., 116:353-7.
Ho¨chter W, Chase D, Hegenhoff G. 1990. Saccharomyces boulardii in treatmentof acute adult diarrhoea: efficacy and tolerance of treatment.Mu¨nch Med Wochen., 132:188-92.
Isolauri E, Arvola T, Sutas Y, Moilanen E, Salminen S. 2000. Probiotics inthe management of atopic eczema. Clin Exp Allergy 30:1604-10.
Isolauri E, Juntunen M, Rautanen T, Sillanaukee P, Koivula T. 1991. Ahuman Lactobacillus strain (Lactobacillus Casei sp strain GG) promotesrecovery from acute diarrhea in children. Pediatrics 88:90-7.
Isolauri E, Kaila M, Mykkänen H, Ling WH, Salminen S. 1994. Oral bacteriotherapy for viral gastroenteritis. Dig Dis Sci., 39:2595-600.
Kaila M, Isolauri E, Saxelin M, Arvilommi H, Vesikari T. 1995. Viable versus inactivated Lactobacillus strain GG in acute rotavirus diarrhoea. Arch Dis Child 72:51-3.
Kaila M, Isolauri E, Virtanen E, Laine S, Arvilommi H. 1992. Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatr Res., 32:141-4.
Kalliomaki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. 2001. Probiotics in primary prevention of atopic disease: a randomized placebocontrolled trial. Lancet 357:1076-9.
Kalliomaki M, Salminen S, Poussa T, Arvilommi H, Isolauri E. 2003. Probioticsand prevention of atopic disease: 4-year follow-up of a randomized placebocontrolled trial. Lancet 361:1869-71.
Khedkar CD, Garge RD, Mantri JM, Kulkarni SA, Khedkar GD. 1993. Effect of feeding acidophilus milk on serum cholesterol in human volunteers. J Dairy Foods Home Sci., 12:33-8.
Kim HS, Gilliland SE. 1983. Lactobacillus acidophilus as dietary adjunct formilk to aid lactose digestion in humans. J Dairy Sci., 66:959-66.
Klaenhammer TR, Kullen MJ. 1999. Selection and design of probiotics. Int J Food Microbiol., 50:45-57.
Klaver FAM, Van der Meer R. 1993. The assumed assimilation of cholesterolby Lactobacilli and Bifidobacterium bifidum is due to their bilesaltdeconjugating activity. Appl Environ Microbiol., 59:1120-4.
Klebanoff SJ, Coombs RW. 1991. Viricidal effect of Lactobacillus acidophiluson human immunodeficiency virus type 1: possible role in heterosexual transmission. J Exp Med., 174:289-92.
Klein G, Pack A, Bonaparte C, Reuter G. 1998. Taxonomy and physiology of probiotic lactic acid bacteria. Int J Food Microbiol., 41:103-25.
Kolars JC, Levitt MD, Aouj M, Savaino DA. 1984. Yogurt-an antidigestingsource of lactose. N Engl J Med., 310:1-3.
Lee Y-K, Salminen S. 1995. The coming of age of probiotics. Trends FoodSci Technol., 6:241-5.
Lin SY, Ayres JW, Winkler W, Sandine WE. 1989. Lactobacillus effects oncholesterol: in vitro and in vivo results. J Dairy Res., 72:2885-99.
Majamaa H, Isolauri E. 1997. Probiotics: a novel approach in the managementof food allergy. J Allergy Clin Immunol., 99:179-85.
Majamaa M, Isolauri E, Saxelin M, Vesikari T. 1995. Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr., 20:333-8.
Mastretta E, Longo P, Laccisaglia A. 2002. Effect of Lactobacillus GGand breast-feeding in the prevention of rotavirus nosocomial infection. J Pediatr Gastroenterol Nutr., 35:527-31.
McFarland LV, Elmer GW. 1997. Pharmaceutical probiotics for the treatment of anaerobic and other infections. Anaerobe 3:73-8.
Medaglini D, Oggioni MR, Pozzi G. 1998. Vaginal immunization with recombinant gram-positive bacteria. Am J Reprod Immunol., 39:199-208.
Michail S, Wei S, Mack DR. 1997. Escherichia coli strain E2348/69 in vitroadhesion is reduced in the presence of a Lactobacillus species [abstract]. Gastroenterology 112:A1042.
Miettinen M, Matikainen S, Vuopio-Varkila J. 1998. Lactobacilli and streptococci induce interleukin-12 (IL12), IL-18, and gamma interferonproduction in human peripheral blood monocellular cells. InfectImmun., 66:6058-62.
Naidu AS, Bidlack WR, Clemens RA. 1999.. Probiotic spectra of lactic acid bacteria (LAB). Crit Rev Food Sci Nutr., 39:13-126.
Nanno M, Ohwaki M, Mutai M. 1986. Induction of Lactobacillus casei ofincrease in macrophage colonyforming cells and serum colony-stimulatingactivity in mice. Jpn J Cancer Res., 77:703-10.
Nase L, Hatakka K, Savilahti E. 2001. Effect of longterm consumptionof a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dentalcaries and caries risk in children. Caries Res., 35:412-20.
Oberhelman RA, Gilman RH, Sheen P. 1999. A placebo-controlled trialof Lactobacillus GG to prevent diarrhea in undernourished Peruvianchildren. J Pediatr., 134:15-20.
Ouwehand AC. 2007. Antiallergic Effects of Probiotics. J. Nutr., 137:794-797.
Pant AR, Graham SM, Allen SJ. 1996. Lactobacillus GG and acutediarrhea in young children in the tropics. J Trop Pediatr., 42:162-5.
Perdigon G, de Macias ME, Alvarez S. 1986. Effect of periorally administrated Lactobacilli on macrophage activation in mice. Infect Immun., 53:404-10.
Pereira DIA, Gibson GR. 2002. Effects of Consumption of Probiotics and Prebiotics on Serum Lipid Levels in Human.Crit. Rev. Biochem. Mol. Biol., 37:259-281.
Pothoulakis C, Kelly CP, Joshi MA. 1993. Saccharomyces boulardiiinhibits Clostridium difficile toxin A binding and enterotoxicity in ratileum. Gastroenterology 104:1108-15.
Rautava S, Kalliomaki M, Isolauri E. 2002. Probiotics during pregnancy andbreast-feeding might confer immunomodulatory protection againstatopic disease in the infant. J Allergy Clin Immunol., 109:119-21.
Raza S, Graham SM, Allen SJ, Sultana S, Cuevas L, Hart CA. 1995. Lactobacillus GG promotes recovery from acute nonbloody diarrhea in Pakistan.Pediatr Infect Dis J., 14:107-11.
Reid G, Jass J, Sebulsky T. 2003. Treatment of Acute Rota Virus Diarrhoea in Children. Potential Uses of Probiotics in Clinical Practice Revised.
Rigothier MC, Maccanio J, Gayrol P. 1994. Inhibitory activity of Saccharomycesyeasts on the adhesion of Entamoeba histolytica trophozoitesto human erythrocytes in vitro. Parasitol Res., 80:10-5.
Salminen S, Laine M, von Wright A, Vuopio-Varkila J, Korhonen T, Mattila-Sandholm T. 1996. Development of selection criteria for probioticstrains to assess their potential in functional foods: a Nordic and European approach. Biosci Microflora15:61-7.
Sanders ME. 2006. Summary of probiotic activities of Bifidobacterium lactis HN019. J Clin Gastroenterol., 40:776-83.
Sepp E, Tamm E, Torm S, Lutsar I, Mikelsaar M, Salminen S. 1995. Impact of a Lactobacillus probiotic on the faecal microflora in children withshigellosis. Microecol Ther., 23:74 -80.
Shornikova AV, Cosas I, Mykkanen H, Salo E, Vesikari T. 1997. Bactiotherapywith Lactobacillus reuteri in rotavirus gastroenteritis. Pediatr Infect Dis. J. 16:1103-7.
Shornikova AV, Isolauri E, Burkanova L, Lukovnikova S, Vesikari T. 1997. Atrial in the Karelian Republic of oral rehydration and Lactobacillus GGfor treatment of acute diarrhea. Acta Paediatr., 86:460-5.
Silva M, Jacobus NV, Deneke C, Gorbach SL. 1987. Antimicrobial substancefrom a human Lactobacillus strain. Antimicrob Agents Chemother., 31:1231-3.
Songisepp E, Kulisaar T, Hütt P, Elias P, Brilene T Zilmer M, Mikelsaar M. 2004. A New Probiotic Cheese with Antioxidative and Antimicrobial. J. Dairy Sci., 87:2017-2023.
Szajewska H, Kotowska M, Murkowicz JZ, Armanska M, Mikolajczyk W. 2001. Efficacy of Lactobacillus GG in prevention of nosocomial diarrheain infants. J Pediatr., 138:361-5.
Tahri K, Ballongue J, Schneider F. 1995. Effects of three strains of bifidobacteriaon cholesterol. Lett Appl Microbiol., 21:149-51.
Van’t Veer P, Dekker JM, Lamers JWJ. 1989. Consumption of fermented milk products and breast cancer: a case-control study in the Netherlands. Cancer Res., 49:4020-3.
Weston S, Halbert A, Richmond P, Prescott SL. 2005. Effects of Probiotics on Topic Dermatitis: A Randomised Controlled Trial. Arch. Dis. Child 90:892-897.
Wilson KH, Perini I. 1988. Role of competition for nutrients in suppression of Clostridium difficile by the colonic microflora. Infect Immun., 56:2610-4.
Yeo SK, Liong MT. 2010. AngiotensinI-Converting Enzyme Inhibitory Activity and Bioconversion of Isoflavones by Probiotics in Soymilk Supplemented with Prebiotics.Int. J. Food Sci. Nutr., 61:161-181.
