Hypoglycemic effect of inositol (IP6 as nutritional supplement) on streptozotocin induced type II diabetes mellitus in rats
Keywords:
Inositol, Hypoglycemic activity
Abstract
In this research, a water soluble vitamin B8 (Inositol) sometimes referred to as phytic acid which has been shown to be effective in treating diabetes mellitus was used to study the hypoglycemic effect. Banana, grapes and orange are the rich inositol food source. The study shows that inositol has anti-diabetic effect on streptizotocin induced diabetic rats and has potential use as a hypoglycemic agent.
References
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Adikwu MU, Yoshikawa Y and Takada K. 2004. Pharmacodynamic-pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic properties in streptozotocin induced diabetic rate models. Biomaterials, 25(15): 3041-3048.
Kim SW, Hwang HJ, Cho E.J, Oh JY, Back YM, Choi JM and Yun JW. 2006. Time – dependent plasma protein changes in streptozoticin – induced diabetic rats before and after fungal polysaccharide treatments. Journal of Protcome Research, 5(11): 2966-2976.
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Montilla, P, Barcos M, Munoz MC, Muno castaneda, JR, Bujalance I and Tunez I. 2004. Protective effect of Montilla – moriles appellation red wine on oxidative stress induced by streptozotocin in the rat. The Journal of National Biochemistry, 15(11): 688-693.
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Tsai HC, Wasser FA, Yang SP and Huang BM. 2006. Effects of ingested fruiting bodies, submerged culture biomass and acidic polysaccharide glucuronoxylomannan of Tremella mesenterica Retz, Fr. on glycemic responses in normal and diabetic rats. Life Science, 78(17): 1957-1966.
Adikwu MU, Yoshikawa Y and Takada K. 2004. Pharmacodynamic-pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic properties in streptozotocin induced diabetic rate models. Biomaterials, 25(15): 3041-3048.
Kim SW, Hwang HJ, Cho E.J, Oh JY, Back YM, Choi JM and Yun JW. 2006. Time – dependent plasma protein changes in streptozoticin – induced diabetic rats before and after fungal polysaccharide treatments. Journal of Protcome Research, 5(11): 2966-2976.
Kuppusamy, Muthusamy U, Thirumalaisamy SA, Varadharajan S, Ramasamy K, Ramanathan S and Asokkumar. 2011. Invitro (β-Glucosidare and β-Amylase Inhibition) and in vivo antidiabetic property of phytic acid (IP6) in streptozotocin-nicotinamide-induced type 2 – diabetes mellitus (NIDDM) in rats, Journal of Complementary and Integrative Medicine, 8(1).
Montilla, P, Barcos M, Munoz MC, Muno castaneda, JR, Bujalance I and Tunez I. 2004. Protective effect of Montilla – moriles appellation red wine on oxidative stress induced by streptozotocin in the rat. The Journal of National Biochemistry, 15(11): 688-693.
Sharon M and Nutrients AZ. 2005. User’s guide to foods, herbs, vitamins, minerals and supplements. 3rd ed. London, UK: Carbon Books.
Tsai HC, Wasser FA, Yang SP and Huang BM. 2006. Effects of ingested fruiting bodies, submerged culture biomass and acidic polysaccharide glucuronoxylomannan of Tremella mesenterica Retz, Fr. on glycemic responses in normal and diabetic rats. Life Science, 78(17): 1957-1966.
Published
2014-07-27
How to Cite
A, H. T. R., N, M., & britto, A. J. de. (2014). Hypoglycemic effect of inositol (IP6 as nutritional supplement) on streptozotocin induced type II diabetes mellitus in rats. Journal of Research in Biology, 4(5), 1397-1401. Retrieved from https://ojs.jresearchbiology.com/ojs1/index.php/jrb/article/view/356
Section
Articles
