Oxidative stress as a significant contributor in the pathogenesis and white cell changes in pre-eclampsia: A study in Owerri, Nigeria
Abstract
Haeomatological and oxidative stress parameters were measured in Pre-eclamptic [PE] women attending clinic in owerri South Eastern Nigeria. The effect of Pre-eclampsia on these parameters was assessed by juxtaposition with similar indices in normal pregnant and normal non-pregnant women. Result showed that pre-eclampia resulted in significant decrease (P< 0.05) in Lymphocyte count. There was a significant increase in total white blood cell count, neutrophil count and mixed differential count. Pre-eclamptic resulted in significant increase (P<0.05) in erythrocyte lipid peroxidation, met-haemoglobin concentration and percentage hydrogen peroxide-induced haemolysis. The result indicate that oxidative stress is a significant contributor in the pathogenesis and white cell changes seen in pre-eclampsia.
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